The novel quinolizidine derivate IMB-HDC inhibits STAT5a phosphorylation at 694 and 780 and promotes DNA breakage and cell apoptosis via blocking STAT5a nuclear translocation
نویسندگان
چکیده
منابع مشابه
Escorting STAT5A
ome transcription factors take a chaperone to the nuclear dance. On page 469, Williams et al. show that STAT5A gets this escort from the ERBB4 receptor tyrosine kinase. ERBB4 becomes an escort upon activation by growth factors such as heregulin (HRG). The activated receptor is known to recruit and phos-phorylate STAT5A and get cleaved, thus releasing ERBB4's intracellular domain (4ICD). William...
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ژورنال
عنوان ژورنال: Acta Pharmacologica Sinica
سال: 2020
ISSN: 1671-4083,1745-7254
DOI: 10.1038/s41401-019-0333-6